Tazarotene triggers

a range of activities in the skin1-6


Rapid conversion

Tazarotene is rapidly converted in the skin to its active form (tazarotenic acid) for direct delivery with low systemic exposure.7,8

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Preferential activation

Activates 2 retinoic acid receptors, RAR-β and RAR-γ.
RAR-γ is the most predominant in human skin.9


  • Reduces keratinocyte proliferation1
  • Normalizes keratin production2
  • Exerts anti-inflammatory effects3
  • Promotes collagen production3,4
  • Modulates scarring and post-inflammatory hyperpigmentation5,6

*The clinical significance of these findings in acne is unknown.