Unique Formulation

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EXPLORE THE UNIQUE MECHANISM OF DELIVERY FOR ARAZLO LOTION

Watch and learn how patented polymeric emulsion technology distributes tazarotene evenly to reduce irritation, facilitates rapid absorption of hydrating excipients that strengthen barrier function, to deliver the clearance you expect and the tolerability you want1-5

Even Distribution

Formulated to distribute evenly and reduce irritation1

The vehicle in ARAZLO Lotion features a honeycomb mesh that spreads tazarotene evenly on the skin.1

The clinical significance of the formulation has not been established.

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When applied, the honeycomb mesh distributes the oil droplets evenly on the skin1

The oil droplets are trapped within the ARAZLO Lotion patented honeycomb mesh1

Tazarotene is encapsulated within oil droplet1

Barrier Function

Improves barrier function2

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In addition to the tazarotene-containing oil droplets, the honeycomb mesh evenly distributes moisturizing components that form a barrier to help keep the skin from losing moisture.1

  • 8 hours after vehicle application the skin barrier was 51% more effective at retaining water than at baseline2
Study design
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The transepidermal water loss (TEWL) and moisture content of skin sites treated with ARAZLO Lotion vs untreated sites were measured in 30 patients at baseline, 15 minutes, 30 minutes, 1 hour, 2 hours, 3 hours, 8 hours, and 24 hours. Evaluations were made by a trained technician using the tewameter and corneometer.2

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Improves water retention2

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  • 15 and 30 minutes after vehicle application, there was 107% more water in the skin than at time 0 as measured by corneometry2
  • 24 hours after application, the water content in the skin was 38% greater than at baseline2
Study design
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The transepidermal water loss (TEWL) and moisture content of skin sites treated with ARAZLO Lotion vs untreated sites were measured in 30 patients at baseline, 15 minutes, 30 minutes, 1 hour, 2 hours, 3 hours, 8 hours, and 24 hours. Evaluations were made by a trained technician using the tewameter and corneometer.2

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Patient Friendly

Designed to promote patient acceptance1

Excipients with hydrating properties include1:

  • Diethyl sebacate
  • Light mineral oil
  • Sorbitol solution, 70%

In a survey, 100% of patients (N=15) strongly agreed or agreed that the ARAZLO Lotion vehicle had these qualities1,2:

  • Absorbed quickly
  • Did not feel greasy
  • Had a lightweight after-feel
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Study design
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15 female subjects between the ages of 35 and 65 applied the assigned lotion vehicle to the right side of their faces while leaving the left side untreated. Afterward, they answered a questionnaire to assess their satisfaction.2

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